Set in Japan, Isle of Dogs follows a boy's odyssey in search of his lost dog. Using stop-motion-animation writer/director Wes Anderson (Moonrise Kingdom, Rushmore) to tell the story of dogs who are quarantined in an island after the outbreak of a canine flu. The boy (voiced by Koyu Rankin) who journeys there to rescue his dog Spots (Liev Schreiber), gets help from a pack of misfit canines who have also been exiled. His quest inspires a group of dog lovers to expose a government conspiracy. The voice cast also includes Bryan Cranston, Edward Norton, Bill Murray, Scarlett Johansson, Tilda Swinton, Bob Balaban, Greta Gerwig, and Yoko Ono.